Anesthesia and Neurotoxicity
نویسندگان
چکیده
منابع مشابه
Update on developmental anesthesia neurotoxicity.
PURPOSE OF REVIEW Adverse long-term impact of general anesthesia on the developing brain is a widely discussed and controversial issue with potential public health relevance. The goal of this article is to give insights into the most recent experimental and clinical observations aimed to advance our understanding in this field. RECENT FINDINGS Recent investigations demonstrate long-term behav...
متن کاملAnesthesia and neurotoxicity to the developing brain: the clinical relevance.
Laboratory work has confirmed that general anesthetics cause increased neuronal apoptosis and changes to the morphology of dendritic spines in the developing brains of animals. It is an effect seen with most volatile anesthetics as well as with ketamine and propofol. The effects are dose dependent and seen over particular periods of early development. There is some evidence that rodents exposed...
متن کاملNeurotoxicity of general anesthetics: anesthesia and Alzheimer's disease in Serbia.
A large body of preclinical as well as some retrospective clinical evidence suggest that exposure to general anesthesia could be detrimental to cognitive development in young subjects, and might also contribute to accelerated cognitive decline in the elderly. Though general anesthetics have now been used clinically for well over a century, both their mechanisms of action as well as the nature o...
متن کاملPediatric anesthesia neurotoxicity: an overview of the 2011 SmartTots panel.
Through the years, care of millions of premature infants and young children has resulted in numerous exposures to a variety of anesthetic and sedative agents. These agents, designed to achieve the substantial depth of neuronal inhibition required for complete loss of consciousness and insensitivity to pain, are often a necessary component of successful treatment. However, data collected in anim...
متن کاملAnesthesia-induced neurotoxicity in an animal model of the developing brain: mechanism and therapies
Children are being exposed to an increasingly greater variety of anesthetics with advances in pediatric and obstetric surgery. Recent animal and retrospective human data suggest that the general anesthetics commonly used in pediatric medicine could be damaging to the developing brain when used at clinical concentrations. In vivo primate and rodent models have shown that neonatal exposure to cli...
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ژورنال
عنوان ژورنال: Anesthesia & Analgesia
سال: 2018
ISSN: 0003-2999
DOI: 10.1213/ane.0000000000003474